From poly- to isothermal solubility data – efficient and fast anti-solvent mediated crystallization design

  • Crystallization
  • 15 April 2025, Online

About

In this webinar, guest speaker Marco Rudolf van Rohr, Scientific Specialist at CARBOGEN AMCIS, shares insights into his research with the Crystal16.

The webinar provides useful tools which allow solubility data processing to enhance anti-solvent crystallization design. The focus is on how to convert solubility data in different solvent mixtures into saturation isotherms. These isotherms are the basis for efficient process design, significantly reducing the amount of batch experiments. This strategy further informs on synergistic solubility behaviour, the mode of anti-solvent addition and potential seeding of a supersaturated system. The talk covers two different real life examples from pharmaceutical industry. 

Watch the webinar video recording using the form on this page or download the webinar presentation slides from the Publications section.

Guest speaker

Marco Rudolf van Rohr

Scientific Specialist at CARBOGEN AMCIS

I started my chemical career 2009 as a lab technician, taking care of synthesis of small molecules and peptides. Some years later, I studied industrial chemistry at the University of Applied Sciences in Zurich and got my Bachelor’s degree in the field of Physical Chemistry. My first employer after graduation was Switzerland-based CARBOGEN AMICS AG, where I still work, now in my ninth year. I started in the production department where I learned a lot about hands-on chemical production, up to 630 L pilot scale. After this short-term production period, I moved to the R&D department, where I was most of the time occupied with process familiarization and up-scaling questions. Five years ago, I moved from the daily business small molecule R&D to CARBOGEN AMCIS’ specialists team. I started to intensively work on crystallization development and the profound characterization of solid phases. The most common challenges during my time in this team, became evident during up-scaling. So, my work is, unsurprisingly, strongly associated with technical questions. I would describe myself as some sort of chemical engineer in the field of solid state chemistry.

Watch webinar recording