Enabling small-scale analysis during crystallization screening through a single platform

  • Crystallization
  • 12 December 2023

About the webinar

More than 80% of formulations are in the solid state, with most as tablets due to ease of transport, application and high patient compliance. Therefore, a well-designed and controlled crystallization process is paramount. However, this can be a time and material consuming process, as it can take multiple experiments to deliver the required results.

There are several particle parameters that are important to control during crystallization. Arguably the most significant are form purity, particle shape and particle size distribution - due to their legal and manufacturing implications.

This webinar explores how Crystalline V2 can be an ideal platform for crystallization development. We start with looking at solubility information, which is the foundation of any crystallization process. Then we demonstrate how, by using integrated Raman, you can track solid form. Finally, we discuss how it is possible to visualize crystal size and shape in real time with the use of AI particle detection, at the milliliter scale.

Watch the webinar video recording using the form on this page or download the webinar presentation slides from the Publications section.

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Presenter

Thomas Kendall

Application Specialist at Technobis 

Thomas has 9 years of experience in solid form and crystallization development in the pharmaceutical sector. He earned his PhD in Chemical Engineering with CMAC at the University of Strathclyde, investigating nucleation mechanisms in pharma systems. He previously worked for Pharmorphix (part of Johnson Matthey) as a solid form scientist investigating customer compounds in pharma and agro sector.  With extensive experience in polymorph, salt, and co-crystal screening, as well as crystallization development using process analytical technologies, experiments, and modelling software up to kilogram scale, Thomas has authored several patents, webinars, and a book chapter on solid form and crystallization development.

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