Crystallization Screening

  • Application note
  • September 26, 2021
About the author

The study was conducted at Radboud University Nijmegen, Solid State Chemistry Department (The Netherlands). Results and pictures courtesy of Evelien Huijs and Dr. Hugo Meekes.

Improve and accelerate your crystallization screening

Every day, new compounds are produced within food, personal care, dye, agro and pharmaceutical industry. These compounds are getting more and more complex, making dosage determination and formulation more difficult.

In order to obtain the solid state form with desired properties, solid state screening needs to be performed. Polymorph, cocrystal, salt screening, amorphous solid dispersion are most common solid state screening methods of which, polymorph screening is still most widely applied.

This application notes discusses how to drastically increase productivity and efficiency without compromising on flexibility, by using the CrystalBreeder and Crystal16 instruments to automate the execution of crystallization experiments.

Content overview:
  • Basic steps into crystallization screening
  • Control your crystallization parameters
  • Typical crystallization set-up
  • An example of polymorph screening
  • Screen more with less

Download application note